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Counterion

A counterion is the charged species that pairs with a peptide to form a neutral salt. Common peptide counterions are trifluoroacetate (TFA) and acetate. The counterion affects net peptide content

Related terms

  • TFA salt vs acetate salt — TFA salt and acetate salt are the two most common peptide salt forms.
  • Peptide content vs purity — Peptide content and purity are two different measurements.
  • Lyophilization — Lyophilization is freeze-drying: water is removed from the frozen peptide solution under vacuum.
  • SPPS — SPPS (solid-phase peptide synthesis) is the standard manufacturing method for therapeutic and cosmetic peptides.

Category: chemistry · Part of our peptide glossary · Sourcing question? Ask our engineers — replies within 4 business hours.